Reproduction Abstracts

The role of cumulus cells during in vitro maturation is essential for proper oocyte maturation and acquisition of its developmental competence. During development of ovarian follicle, cumulus cells undergo expansion, leading to extracellular matrix production (mainly hyaluronic acid), regulated by various intracellular signaling cascades. Moreover, cumulus cells metabolize glucose to pyruvate or lactate, substrates used by oocyte for its growth and maturation. We demo...

In cow, lysophosphatidic acid (LPA) stimulated synthesis and secretion of luteotropic factors in ovary, which affected growth and development of ovarian follicles. Theca cells, among other components of ovarian follicle, play an essential role in ovulation, which depends on intrafollicular prostaglandin synthesis. In bovine reproductive tract, modulation of prostaglandin synthesis occurs under influence of LPA. Thus, the aim of this study was to determine possible correlation ...

Mural granulosa cells participate in development and differentiation of ovarian follicle. In bovine reproductive system, LPA is involved in autocrine and paracrine signaling, through LPA receptors (LPAR)s. We demonstrated before that LPA modulated prostaglandin (PG) synthesis in uterus and ovary and stimulated estradiol (E2) synthesis in granulosa cells in bovine follicle. As the ovarian follicle development and differentiation leading to oocyte ovulation depend on ...